What causes the body to age?


As we age, the level of NAD+ in the body continues to decrease, leading to the function decline of mitochondria (a.k.a. biological energy generator). That triggers aging in the end. The level of NAD+ decreases as we age over the years. Generally the decrease process gets significantly faster after we pass the age of 30, resulting in an acceleration of ageing.



SUPPORTS HEALTHY AGING

NAD+ keeps long telomeres working efficiently


HELPS DNA REPAIR

NAD+ is involved in the repair of DNA that has been damaged from normal day-to-day exposures and processes.



PROTECTS CELLS FROM STRESS

NAD+ makes cells resistant to stress and protects the brain.


PROVIDE ENERGY TO CELLS

NAD+ boosts mitochondria (a.k.a. biological energy generator) activity


Boosting NAD+ level is the key of anti-ageing


Recent medical research has found that when the body’s NAD+ is elevated, the functions of one’s brain, nervous system, cardiovascular system, muscle system, all internal organs and reproductive system can be restored to the level as they were young.



How to boost NAD+ level?


The simple answer is taking NAD+ pills or injecting it into the body. However, it is not practical in daily life, because NAD+ is an unstable compound. It becomes inactive right away as soon as being exposed to the air. If we intake it directly, NAD+ will be broken down into other compounds and destroyed before it can be absorbed. If we inject NAD+ into the body, we have to maintain the dose every day, which is inconvenient for everyday use. Therefore, currently the best way is to take NAD+ precursor, so that our body can use the precursor to make our own NAD+.



The 5 NAD+ precursors


There are five types of NAD+ precursors. They are NA (nicotinic acid), tryptophan (Trp) nicotinamide (NAM), nicotinamide ribose (NR) and nicotinamide mononucleotide (NMN).


  • Chemical Structure

  • PROPRO
  • CONCON
  • CommentComment
  • NA

  • PROTreatment of pellagra, Reduce cholesterol, Cheap
  • CONFacial flushing, Harmful to insulin metabolism, Not a suitable NAD+ precursor for many important cells
  • CommentCan not achieve NAD+ related anti-aging effect.
  • NAM

  • PROFair price, boost NAD+ in certain cells
  • CONThe effect decreases with age and pressure, Affect SIRT activities, Conversion to NAD+ is restricted by rate-limiting enzyme NAMPT
  • CommentAnti-aging effects decay with time, Inhibit Sirt activity
  • NR

  • PROEasy absorption, High efficiency, Clinical trial done
  • CONNR supplements are non-natural but chlorinated NR, damage muscle
  • CommentAvailable as health supplement
  • NMN

  • PROSame Pro as NR, but in vivo distribution and bioavailability is better than NR
  • CONNo reported side effect yet
  • CommentAvailable as health supplement

What is NMN?


NMN is the abbreviation of Nicotinamide Mononucleotide. It is a biologically active nucleotide naturally present in the human body. It is widely involved in many biochemical reactions in the human body and can directly affect human life span, immunity, and metabolism. As the precursor of NAD+, NMN is currently an ideal way to supplement NAD+.


Different NMN has completely different activity


The difference between Alpha NMN and Beta NMN. NMN is divided into two types, one is called alpha NMN (alpha NMN), and the other is called beta-NMN (beta NMN). These two substances have the same molecular weight and similar chemical structure, but the spatial structure is very different. alphaNMN has no biological activity and is useless after eating. It's like a person's left hand and right hand. Although they look exactly the same, the gloves for the left hand will definitely not match. In order to save costs on the premise that some NMN products can pass the inspection, a large amount of Alpha NMN is added, resulting in a lack of effect. Only beta NMN can exercise its anti-aging effect.



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